Pharmacokinetics of Anti‐VEGF Agent Aflibercept in Cancer Predicted by Data‐Driven, Molecular‐Detailed Model

Mathematical models can support the drug development process by predicting the pharmacokinetic (PK) properties of the drug and optimal dosing regimens. We have developed a pharmacokinetic model that includes a biochemical molecular interaction network linked to a whole‐body compartment model. We app...

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Detalles Bibliográficos
Autores principales: Finley, SD, Angelikopoulos, P, Koumoutsakos, P, Popel, AS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716581/
https://www.ncbi.nlm.nih.gov/pubmed/26783500
http://dx.doi.org/10.1002/psp4.12040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716581/
https://www.ncbi.nlm.nih.gov/pubmed/26783500
http://dx.doi.org/10.1002/psp4.12040

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