A Systems Pharmacology Model for Predicting Effects of Factor Xa Inhibitors in Healthy Subjects: Assessment of Pharmacokinetics and Binding Kinetics

Factor Xa (FXa) emerged as a promising target for effective anticoagulation and several FXa inhibitors are now available for the prevention of venous thromboembolism. However, in previously reported pharmacokinetic/pharmacodynamic (PK/PD) models, the complex coagulation processes and detailed inform...

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Detalles Bibliográficos
Autores principales: Zhou, X, Huntjens, DRH, Gilissen, RAHJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716584/
https://www.ncbi.nlm.nih.gov/pubmed/26783501
http://dx.doi.org/10.1002/psp4.12035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716584/
https://www.ncbi.nlm.nih.gov/pubmed/26783501
http://dx.doi.org/10.1002/psp4.12035

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