Use of Modeling and Simulation in the Design and Conduct of Pediatric Clinical Trials and the Optimization of Individualized Dosing Regimens

Mathematical models of drug action and disease progression can inform pediatric pharmacotherapy. In this tutorial, we explore the key issues that differentiate pediatric from adult pharmacokinetic (PK) / pharmacodynamic (PD) studies, describe methods to calculate the number of participants to be enr...

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Detalles Bibliográficos
Autores principales: Stockmann, C, Barrett, JS, Roberts, JK, Sherwin, CMT
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Tutorials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716585/
https://www.ncbi.nlm.nih.gov/pubmed/26783499
http://dx.doi.org/10.1002/psp4.12038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716585/
https://www.ncbi.nlm.nih.gov/pubmed/26783499
http://dx.doi.org/10.1002/psp4.12038

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