Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

The Dna2 nuclease-helicase maintains genomic integrity by processing DNA double-strand breaks, Okazaki fragments and stalled replication forks. Dna2 requires ssDNA ends, and is dependent on the ssDNA-binding protein Rpa, which controls cleavage polarity. Here we present the 2.3 Å structure of intact...

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Detalles Bibliográficos
Autores principales: Zhou, Chun, Pourmal, Sergei, Pavletich, Nikola P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716839/
https://www.ncbi.nlm.nih.gov/pubmed/26491943
http://dx.doi.org/10.7554/eLife.09832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716839/
https://www.ncbi.nlm.nih.gov/pubmed/26491943
http://dx.doi.org/10.7554/eLife.09832

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