EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling

Autocatalytic activation of epidermal growth factor receptor (EGFR) coupled to dephosphorylating activity of protein tyrosine phosphatases (PTPs) ensures robust yet diverse responses to extracellular stimuli. The inevitable tradeoff of this plasticity is spontaneous receptor activation and spurious...

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Detalles Bibliográficos
Autores principales: Baumdick, Martin, Brüggemann, Yannick, Schmick, Malte, Xouri, Georgia, Sabet, Ola, Davis, Lloyd, Chin, Jason W, Bastiaens, Philippe IH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716840/
https://www.ncbi.nlm.nih.gov/pubmed/26609808
http://dx.doi.org/10.7554/eLife.12223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716840/
https://www.ncbi.nlm.nih.gov/pubmed/26609808
http://dx.doi.org/10.7554/eLife.12223

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