Cargando…

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

T follicular helper cells (Tfh) are critical for the longevity and quality of antibody-mediated protection against infection. Yet few signaling pathways have been identified to be unique solely to Tfh development. ROQUIN is a post-transcriptional repressor of T cells, acting through its ROQ domain t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramiscal, Roybel R, Parish, Ian A, Lee-Young, Robert S, Babon, Jeffrey J, Blagih, Julianna, Pratama, Alvin, Martin, Jaime, Hawley, Naomi, Cappello, Jean Y, Nieto, Pablo F, Ellyard, Julia I, Kershaw, Nadia J, Sweet, Rebecca A, Goodnow, Christopher C, Jones, Russell G, Febbraio, Mark A, Vinuesa, Carola G, Athanasopoulos, Vicki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716841/ https://www.ncbi.nlm.nih.gov/pubmed/26496200 http://dx.doi.org/10.7554/eLife.08698

Ejemplares similares

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis
por: Srivastava, Monika, et al.
Publicado: (2015)

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres
por: Pratama, Alvin, et al.
Publicado: (2015)

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
por: Tavernier, S. J., et al.
Publicado: (2019)

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK
por: Morris, Rhiannon, et al.
Publicado: (2021)

Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
por: Tavernier, S. J., et al.
Publicado: (2019)

Small Intestine Inflammation in Roquin-Mutant and Roquin-Deficient Mice
por: Schaefer, Jeremy S., et al.
Publicado: (2013)

Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation
por: Hoefig, Kai P., et al.
Publicado: (2021)

Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice
por: Montufar-Solis, Dina, et al.
Publicado: (2014)

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
por: Linterman, Michelle A., et al.
Publicado: (2010)

Roquin – a multifunctional regulator of immune homeostasis
por: Schaefer, J. S., et al.
Publicado: (2015)

Regnase-1 and Roquin regulate inflammatory mRNAs
por: Mino, Takashi, et al.
Publicado: (2015)

Structural basis for the recognition of transiently structured AU-rich elements by Roquin
por: Binas, Oliver, et al.
Publicado: (2020)

Loss of Roquin induces early death and immune deregulation but not autoimmunity
por: Bertossi, Arianna, et al.
Publicado: (2011)

Identification of new high affinity targets for Roquin based on structural conservation
por: Braun, Johannes, et al.
Publicado: (2018)

Cooperation of RNA-Binding Proteins – a Focus on Roquin Function in T Cells
por: Behrens, Gesine, et al.
Publicado: (2022)

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
por: Lee, Sau K., et al.
Publicado: (2011)

Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
por: Janowski, Robert, et al.
Publicado: (2016)

ROQUIN/RC3H1 Alterations Are Not Found in Angioimmunoblastic T-Cell Lymphoma
por: Auguste, Tiphanie, et al.
Publicado: (2013)

New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins
por: Zhang, Qi, et al.
Publicado: (2015)

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
por: Rehage, Nina, et al.
Publicado: (2018)

The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus
por: Sestan, Mario, et al.
Publicado: (2023)

Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology
por: Blagih, Julianna, et al.
Publicado: (2021)

Follicular helper T cells are required for systemic autoimmunity
por: Linterman, Michelle A., et al.
Publicado: (2009)

The ROQ domain of Roquin recognizes mRNA constitutive decay element and double-stranded RNA
por: Tan, Dazhi, et al.
Publicado: (2014)

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
por: Essig, Katharina, et al.
Publicado: (2018)

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity
por: Schmidt, Henrik, et al.
Publicado: (2023)

Roquin is a major mediator of iron-regulated changes to transferrin receptor-1 mRNA stability
por: Corral, Victor M., et al.
Publicado: (2021)

Dynamic Regulation of the Nexus Between Stress Granules, Roquin, and Regnase-1 Underlies the Molecular Pathogenesis of Warfare Vesicants
por: Srivastava, Ritesh Kumar, et al.
Publicado: (2022)

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
por: Sgromo, Annamaria, et al.
Publicado: (2017)

Analysis of ROQUIN, Tristetraprolin (TTP), and BDNF/miR-16/TTP regulatory axis in late onset Alzheimer’s disease
por: Asadi, Mohammad Reza, et al.
Publicado: (2022)

Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells
por: Mai, David, et al.
Publicado: (2023)

The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1
por: Sobańska, Daria, et al.
Publicado: (2022)

Reducing the search space for causal genetic variants with VASP
por: Field, Matthew A., et al.
Publicado: (2015)

Roquin2 suppresses breast cancer progression by inhibiting tumor angiogenesis via selectively destabilizing proangiogenic factors mRNA
por: Zhou, Meicen, et al.
Publicado: (2021)

Roquin-1 resolves sepsis-associated acute liver injury by regulating inflammatory profiles via miRNA cargo in extracellular vesicles
por: Zheng, Lei, et al.
Publicado: (2023)

Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization
por: Labuschagne, Christiaan F., et al.
Publicado: (2019)

Foxp3(+) follicular regulatory T cells control T follicular helper cells and the germinal center response
por: Linterman, Michelle A., et al.
Publicado: (2011)

Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor Roquin2
por: Choi, Jaewoo, et al.
Publicado: (2018)

NMR-derived secondary structure of the full-length Ox40 mRNA 3′UTR and its multivalent binding to the immunoregulatory RBP Roquin
por: Tants, Jan-Niklas, et al.
Publicado: (2022)

Differential effects of AMPK agonists on cell growth and metabolism
por: Vincent, Emma E., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_v6nbtbg3minltcvijrall471vm