Sustained Release of Triamcinolone Acetonide from an Intratympanically Applied Hydrogel Designed for the Delivery of High Glucocorticoid Doses

The pharmacokinetic properties and tolerability of a triamcinolone acetonide poloxamer 407 hydrogel for intratympanic application were investigated in a guinea pig model. Evaluation of in vivo release kinetics showed very high initial perilymph drug levels, with clinically relevant levels present fo...

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Detalles Bibliográficos
Autores principales: Honeder, Clemens, Engleder, Elisabeth, Schöpper, Hanna, Gabor, Franz, Reznicek, Gottfried, Wagenblast, Jens, Gstoettner, Wolfgang, Arnoldner, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717230/
https://www.ncbi.nlm.nih.gov/pubmed/24714604
http://dx.doi.org/10.1159/000358165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717230/
https://www.ncbi.nlm.nih.gov/pubmed/24714604
http://dx.doi.org/10.1159/000358165

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