Chemical Polysialylation and In Vivo Tetramerization Improve Pharmacokinetic Characteristics of Recombinant Human Butyrylcholinesterase-Based Bioscavengers

Organophosphate toxins (OPs) are the most toxic low-molecular compounds. The extremely potent toxicity of OPs is determined by their specificity toward the nerve system. Human butyrylcholinesterase (hBChE) is a natural bioscavenger against a broad spectrum of OPs, which makes it a promising candidat...

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Detalles Bibliográficos
Autores principales: Terekhov, S. S., Smirnov, I. V., Shamborant, O. G., Bobik, T. V., Ilyushin, D. G., Murashev, A. N., Dyachenko, I. A., Palikov, V. A., Knorre, V. D., Belogurov, A. A., Ponomarenko, N. A., Kuzina, E. S., Genkin, D. D., Masson, P., Gabibov, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717259/
https://www.ncbi.nlm.nih.gov/pubmed/26798501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717259/
https://www.ncbi.nlm.nih.gov/pubmed/26798501

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