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Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice
Combating the social and economic consequences of a growing elderly population will require the identification of interventions that slow the development of age‐related diseases. Preserved cellular homeostasis and delayed aging have been previously linked to reduced cell proliferation and protein sy...
Autores principales: | Thompson, Airlia C. S., Bruss, Matthew D., Price, John C., Khambatta, Cyrus F., Holmes, William E., Colangelo, Marc, Dalidd, Marcy, Roberts, Lindsay S., Astle, Clinton M., Harrison, David E., Hellerstein, Marc K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717272/ https://www.ncbi.nlm.nih.gov/pubmed/26541492 http://dx.doi.org/10.1111/acel.12414 |
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