Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, is characterized by the presence of glucosylcer‐amide macrophages, the accumulation of glucosylceramide in lysosomes and the secretion of inflammatory cytokines. However, the connection between this lysosomal storage and infl...

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Detalles Bibliográficos
Autores principales: Aflaki, Elma, Moaven, Nima, Borger, Daniel K., Lopez, Grisel, Westbroek, Wendy, Chae, Jae Jin, Marugan, Juan, Patnaik, Samarjit, Maniwang, Emerson, Gonzalez, Ashley N., Sidransky, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717273/
https://www.ncbi.nlm.nih.gov/pubmed/26486234
http://dx.doi.org/10.1111/acel.12409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717273/
https://www.ncbi.nlm.nih.gov/pubmed/26486234
http://dx.doi.org/10.1111/acel.12409

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