Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

BACKGROUND: Triple-negative breast cancer (TNBC), an aggressive disease comprising several subtypes including basal-like and claudin-low, involves frequent deletions or point mutations in TP53, as well as loss of PTEN. We previously showed that combined deletion of both tumor suppressors in the mous...

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Detalles Bibliográficos
Autores principales: Wang, Sharon, Liu, Jeff C., Kim, Danbi, Datti, Alessandro, Zacksenhaus, Eldad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717616/
https://www.ncbi.nlm.nih.gov/pubmed/26781438
http://dx.doi.org/10.1186/s13058-015-0668-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717616/
https://www.ncbi.nlm.nih.gov/pubmed/26781438
http://dx.doi.org/10.1186/s13058-015-0668-y

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