Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs

BACKGROUND: Identification of synthetic lethal interactions in cancer cells could offer promising new therapeutic targets. Large-scale functional genomic screening presents an opportunity to test large numbers of cancer synthetic lethal hypotheses. Methods enriching for candidate synthetic lethal ta...

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Detalles Bibliográficos
Autores principales: Wappett, Mark, Dulak, Austin, Yang, Zheng Rong, Al-Watban, Abdullatif, Bradford, James R., Dry, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717622/
https://www.ncbi.nlm.nih.gov/pubmed/26781748
http://dx.doi.org/10.1186/s12864-016-2375-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717622/
https://www.ncbi.nlm.nih.gov/pubmed/26781748
http://dx.doi.org/10.1186/s12864-016-2375-1

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