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Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs

BACKGROUND: Identification of synthetic lethal interactions in cancer cells could offer promising new therapeutic targets. Large-scale functional genomic screening presents an opportunity to test large numbers of cancer synthetic lethal hypotheses. Methods enriching for candidate synthetic lethal ta...

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Detalles Bibliográficos
Autores principales:	Wappett, Mark, Dulak, Austin, Yang, Zheng Rong, Al-Watban, Abdullatif, Bradford, James R., Dry, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717622/ https://www.ncbi.nlm.nih.gov/pubmed/26781748 http://dx.doi.org/10.1186/s12864-016-2375-1

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