p97/VCP promotes Cullin‐RING‐ubiquitin‐ligase/proteasome‐dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα

Cullin‐RING‐ubiquitin‐ligase (CRL)‐dependent ubiquitination of the nuclear factor kappa B (NF‐κB) inhibitor IκBα and its subsequent degradation by the proteasome usually precede NF‐κB/RelA nuclear activity. Through removal of the CRL‐activating modification of their cullin subunit with the ubiquitin...

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Detalles Bibliográficos
Autores principales: Schweitzer, Katrin, Pralow, Alexander, Naumann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717852/
https://www.ncbi.nlm.nih.gov/pubmed/26463447
http://dx.doi.org/10.1111/jcmm.12702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717852/
https://www.ncbi.nlm.nih.gov/pubmed/26463447
http://dx.doi.org/10.1111/jcmm.12702

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