Cargando…

p97/VCP promotes Cullin‐RING‐ubiquitin‐ligase/proteasome‐dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα

Cullin‐RING‐ubiquitin‐ligase (CRL)‐dependent ubiquitination of the nuclear factor kappa B (NF‐κB) inhibitor IκBα and its subsequent degradation by the proteasome usually precede NF‐κB/RelA nuclear activity. Through removal of the CRL‐activating modification of their cullin subunit with the ubiquitin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schweitzer, Katrin, Pralow, Alexander, Naumann, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717852/ https://www.ncbi.nlm.nih.gov/pubmed/26463447 http://dx.doi.org/10.1111/jcmm.12702

Ejemplares similares

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination
por: Li, Haiying, et al.
Publicado: (2011)

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer
por: Tsui, Rachel, et al.
Publicado: (2015)

Distinct B subunits of PP2A regulate the NF‐κB signalling pathway through dephosphorylation of IKKβ, IκBα and RelA
por: Tsuchiya, Yoshihiro, et al.
Publicado: (2017)

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
por: Kabacaoglu, Derya, et al.
Publicado: (2019)

Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα
por: Ivanova, Iglika G., et al.
Publicado: (2019)

Celecoxib Suppresses NF-κB p65 (RelA) and TNFα Expression Signaling in Glioblastoma
por: Ahsan, Hina, et al.
Publicado: (2023)

Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity
por: Aillet, Fabienne, et al.
Publicado: (2012)

NF-κB Repression by PIAS3 Mediated RelA SUMOylation
por: Liu, Yuangang, et al.
Publicado: (2012)

The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation
por: Hochrainer, Karin, et al.
Publicado: (2015)

Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα
por: Hu, Xiaolei, et al.
Publicado: (2020)

IκBα Overexpression Delays Tumor Formation in v-rel Transgenic Mice
por: Carrasco, Daniel, et al.
Publicado: (1997)

AGE-RAGE signal generates a specific NF-κB RelA “barcode” that directs collagen I expression
por: Peng, Yunqian, et al.
Publicado: (2016)

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs
por: Alcamo, Elizabeth, et al.
Publicado: (2002)

PTPIP51—A New RelA-tionship with the NFκB Signaling Pathway
por: Brobeil, Alexander, et al.
Publicado: (2015)

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
por: Ronin, Emilie, et al.
Publicado: (2019)

NFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells
por: Kumar, Vikas, et al.
Publicado: (2022)

Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IκBα in TNFα-stimulated HEK293 cells
por: Lee, Yeji, et al.
Publicado: (2012)

Thr(435) phosphorylation regulates RelA (p65) NF-κB subunit transactivation
por: O'Shea, John M., et al.
Publicado: (2010)

NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells
por: Han, Dongfeng, et al.
Publicado: (2015)

Differential expression of NF-κB heterodimer RelA/p50 in human urothelial carcinoma
por: Durairajan, Sankari, et al.
Publicado: (2018)

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage
por: Campbell, Amy E., et al.
Publicado: (2021)

NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
por: Koerner, Lioba, et al.
Publicado: (2023)

Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IκBα and enhances HIV-1 replication in human T lymphocytes
por: Coiras, Mayte, et al.
Publicado: (2008)

Functional Redundancy of the Nuclear Factor κB Inhibitors IκBα and IκBβ
por: Cheng, Janet D., et al.
Publicado: (1998)

RelA NF-κB subunit activation as a therapeutic target in diffuse large B-cell lymphoma
por: Zhang, Mingzhi, et al.
Publicado: (2016)

Tripartite Motif Containing 52 Positively Regulates NF-κB Signaling by Promoting IκBα Ubiquitination in Lipopolysaccharide-Treated Microglial Cell Activation
por: Zhang, Pei, et al.
Publicado: (2020)

NEDD8 links Cullin–Ring ubiquitin Ligase function to the p97 pathway
por: den Besten, Willem, et al.
Publicado: (2012)

Cyclophilin A (CypA) Interacts with NF-κB Subunit, p65/RelA, and Contributes to NF-κB Activation Signaling
por: Sun, Shan, et al.
Publicado: (2014)

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
por: Lanzillotta, A, et al.
Publicado: (2010)

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
Publicado: (2010)

NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer
por: Geismann, Claudia, et al.
Publicado: (2023)

Involvement of Egr-1/RelA Synergy in Distinguishing T Cell Activation from Tumor Necrosis Factor-α–induced NF-κB1 Transcription
por: Cogswell, Patricia C., et al.
Publicado: (1997)

The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication
por: Lin, Yao-Tang, et al.
Publicado: (2017)

The ubiquitin ligase Cullin5(SOCS2) regulates NDR1/STK38 stability and NF-κB transactivation
por: Paul, Indranil, et al.
Publicado: (2017)

Degradation of Promoter-bound p65/RelA Is Essential for the Prompt Termination of the Nuclear Factor κB Response
por: Saccani, Simona, et al.
Publicado: (2004)

Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65)
por: Du, Haiwei, et al.
Publicado: (2015)

An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF‐induced necroptosis decisions
por: Oliver Metzig, Marie, et al.
Publicado: (2020)

Differential requirements for the canonical NF-κB transcription factors c-REL and RELA during the generation and activation of mature B-cells
por: Milanovic, Maja, et al.
Publicado: (2016)

Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97
por: Chauhan, Anil K., et al.
Publicado: (2020)

The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-κB activity by blocking ubiquitination mediated proteasomal degradation of IκBα in human hepatoma cells
por: Varshney, Bhavna, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cata9lfpbemt0tqdnslt8h8bkl