Cargando…

Prolonged silencing of diacylglycerol acyltransferase‐1 induces a dedifferentiated phenotype in human liver cells

Diacylglycerol acyltransferase‐1 (DGAT1), a key enzyme in triglyceride (TG) biogenesis, is highly associated with metabolic abnormalities, such as obesity and type 2 diabetes. However, the effects of DGAT1 silencing in the human liver have not been elucidated. To investigate the effects of DGAT1 sil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Soyoung, Sung, Pil Soo, Lee, Jungsul, Park, Junseong, Shin, Eui‐Cheol, Choi, Chulhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717863/ https://www.ncbi.nlm.nih.gov/pubmed/26493024 http://dx.doi.org/10.1111/jcmm.12685

Ejemplares similares

Identification of phenotype deterministic genes using systemic analysis of transcriptional response
por: Lee, Jungsul, et al.
Publicado: (2014)

Mitochondrial Network Determines Intracellular ROS Dynamics and Sensitivity to Oxidative Stress through Switching Inter-Mitochondrial Messengers
por: Park, Junseong, et al.
Publicado: (2011)

Evaluation of drug-targetable genes by defining modes of abnormality in gene expression
por: Park, Junseong, et al.
Publicado: (2015)

Phenotypic Modulation of Primary Vascular Smooth Muscle Cells by Short-Term Culture on Micropatterned Substrate
por: Chang, Soyoung, et al.
Publicado: (2014)

Constitutive Expression of MAP Kinase Phosphatase-1 Confers Multi-drug Resistance in Human Glioblastoma Cells
por: Yu, Hana, et al.
Publicado: (2012)

Activities of acyl-CoA:diacylglycerol acyltransferase (DGAT) and phospholipid:diacylglycerol acyltransferase (PDAT) in microsomal preparations of developing sunflower and safflower seeds
por: Banaś, Walentyna, et al.
Publicado: (2013)

Overexpression of Peanut Diacylglycerol Acyltransferase 2 in Escherichia coli
por: Peng, Zhenying, et al.
Publicado: (2013)

Structure and mechanism of human diacylglycerol O-acyltransferase-1
por: Wang, Lie, et al.
Publicado: (2020)

Applications of Diacylglycerol Acyltransferase for Triacylglycerol Production in Mortierella alpina
por: Yu, Ruilin, et al.
Publicado: (2023)

Mutant Ubiquitin Attenuates Interleukin-1β- and Tumor Necrosis Factor-α-Induced Pro-Inflammatory Signaling in Human Astrocytic Cells
por: Choi, Kyungsun, et al.
Publicado: (2013)

Expression of tung tree diacylglycerol acyltransferase 1 in E. coli
por: Cao, Heping, et al.
Publicado: (2011)

Identification of calnexin as a diacylglycerol acyltransferase-2 interacting protein
por: Brandt, Curtis, et al.
Publicado: (2019)

Retraction: Overexpression of Peanut Diacylglycerol Acyltransferase 2 in Escherichia coli
Publicado: (2021)

Functional Characterization of Soybean Diacylglycerol Acyltransferase 3 in Yeast and Soybean
por: Xue, Jinai, et al.
Publicado: (2022)

Effect of Single and Combined Expression of Lysophosphatidic Acid Acyltransferase, Glycerol-3-Phosphate Acyltransferase, and Diacylglycerol Acyltransferase on Lipid Accumulation and Composition in Neochloris oleoabundans
por: Muñoz, Camilo F., et al.
Publicado: (2019)

Structure-Function Analysis of Diacylglycerol Acyltransferase Sequences from 70 Organisms
por: Cao, Heping
Publicado: (2011)

The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function
por: Roe, Nathan D., et al.
Publicado: (2018)

Identification of the major diacylglycerol acyltransferase mRNA in mouse adipocytes and macrophages
por: Cao, Heping
Publicado: (2018)

Functional divergence of diacylglycerol acyltransferases in the unicellular green alga Haematococcus pluvialis
por: Ma, Haiyan, et al.
Publicado: (2020)

A yeast‐based tool for screening mammalian diacylglycerol acyltransferase inhibitors
por: Gajdoš, Peter, et al.
Publicado: (2022)

Suppression of Hepatitis C Virus Genome Replication and Particle Production by a Novel Diacylglycerol Acyltransferases Inhibitor
por: Kim, Dahee, et al.
Publicado: (2018)

Diacylglycerol Acyltransferase-1 (DGAT1) Inhibition Perturbs Postprandial Gut Hormone Release
por: Lin, Hua V., et al.
Publicado: (2013)

A molecular model for diacylglycerol acyltransferase from Mortierella ramanniana var. angulispora
por: Mishra, Sanjay, et al.
Publicado: (2009)

Developmental Regulation of Diacylglycerol Acyltransferase Family Gene Expression in Tung Tree Tissues
por: Cao, Heping, et al.
Publicado: (2013)

Function and Localization of the Arabidopsis thaliana Diacylglycerol Acyltransferase DGAT2 Expressed in Yeast
por: Aymé, Laure, et al.
Publicado: (2014)

Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion
por: Maciejewski, Benjamin S, et al.
Publicado: (2017)

A genome-wide analysis of the phospholipid: diacylglycerol acyltransferase gene family in Gossypium
por: Zang, Xinshan, et al.
Publicado: (2019)

Cocktail biosynthesis of triacylglycerol by rational modulation of diacylglycerol acyltransferases in industrial oleaginous Aurantiochytrium
por: Lan, Chuanzeng, et al.
Publicado: (2021)

A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics
por: Tschapalda, Kirsten, et al.
Publicado: (2016)

Type 1 diacylglycerol acyltransferases of Brassica napus preferentially incorporate oleic acid into triacylglycerol
por: Aznar-Moreno, Jose, et al.
Publicado: (2015)

Nannochloropsis, a rich source of diacylglycerol acyltransferases for engineering of triacylglycerol content in different hosts
por: Zienkiewicz, Krzysztof, et al.
Publicado: (2017)

Characterisation of phospholipid: diacylglycerol acyltransferases (PDATs) from Camelina sativa and their roles in stress responses
por: Yuan, Lixia, et al.
Publicado: (2017)

Heterologous expression of a thermophilic diacylglycerol acyltransferase triggers triglyceride accumulation in Escherichia coli
por: Lázaro, Beatriz, et al.
Publicado: (2017)

Genome-wide identification and expression analysis of diacylglycerol acyltransferase genes in soybean (Glycine max)
por: Zhao, Shihui, et al.
Publicado: (2023)

A phospholipid:diacylglycerol acyltransferase is involved in the regulation of phospholipids homeostasis in oleaginous Aurantiochytrium sp.
por: Zhang, Huidan, et al.
Publicado: (2023)

Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1)
por: Herker, Eva, et al.
Publicado: (2010)

Cloning and Functional Analysis of Three Diacylglycerol Acyltransferase Genes from Peanut (Arachis hypogaea L.)
por: Chi, Xiaoyuan, et al.
Publicado: (2014)

Diacylglycerol O-Acyltransferase Type-1 Synthesizes Retinyl Esters in the Retina and Retinal Pigment Epithelium
por: Kaylor, Joanna J., et al.
Publicado: (2015)

Diversity and evolution of plant diacylglycerol acyltransferase (DGATs) unveiled by phylogenetic, gene structure and expression analyses
por: Turchetto-Zolet, Andreia Carina, et al.
Publicado: (2016)

Variant Amino Acid Residues Alter the Enzyme Activity of Peanut Type 2 Diacylglycerol Acyltransferases
por: Zheng, Ling, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qkjpbfjgic7s0cgrimmcihbe99