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Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity

The catalysis of reactions involving fluoropyruvate as donor by N-acetyl neuraminic acid lyase (NAL) variants was investigated. Under kinetic control, the wild-type enzyme catalysed the reaction between fluoropyruvate and N-acetyl mannosamine to give a 90 : 10 ratio of the (3R,4R)- and (3S,4R)-confi...

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Detalles Bibliográficos
Autores principales:	Stockwell, Jennifer, Daniels, Adam D., Windle, Claire L., Harman, Thomas A., Woodhall, Thomas, Lebl, Tomas, Trinh, Chi H., Mulholland, Keith, Pearson, Arwen R., Berry, Alan, Nelson, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717870/ https://www.ncbi.nlm.nih.gov/pubmed/26537532 http://dx.doi.org/10.1039/c5ob02037a

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