A study on the AMACR catalysed elimination reaction and its application to inhibitor testing

α-Methylacyl-CoA racemase (AMACR; P504S) catalyses a key step in the degradation of branched-chain fatty acids and is important for the pharmacological activation of Ibuprofen and related drugs. Levels of AMACR are increased in prostate and other cancers, and it is a drug target. Development of AMAC...

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Detalles Bibliográficos
Autores principales: Yevglevskis, Maksims, Lee, Guat L., Sun, Jenny, Zhou, Shiyi, Sun, Xiaolong, Kociok-Köhn, Gabriele, James, Tony D., Woodman, Timothy J., Lloyd, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718014/
https://www.ncbi.nlm.nih.gov/pubmed/26537174
http://dx.doi.org/10.1039/c5ob01541c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718014/
https://www.ncbi.nlm.nih.gov/pubmed/26537174
http://dx.doi.org/10.1039/c5ob01541c

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