Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation

The ATP-dependent RNA helicase UPF1, a key factor in nonsense-mediated mRNA decay (NMD), was so far thought to be recruited specifically to NMD-targeted mRNAs by aberrantly terminating ribosomes. However, two recent publications reporting independently transcriptome-wide mapping of UPF1 occupancy on...

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Detalles Bibliográficos
Autores principales: Zünd, David, Mühlemann, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2013
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718051/
https://www.ncbi.nlm.nih.gov/pubmed/26824025
http://dx.doi.org/10.4161/trla.26977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718051/
https://www.ncbi.nlm.nih.gov/pubmed/26824025
http://dx.doi.org/10.4161/trla.26977

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