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Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature
Primary pulmonary non‐Hodgkin's lymphoma (NHL) is very rare. It represents less than 1% of all NHL, and 0.5–1% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL originate from B‐cell lineage. We present a case of a 53‐year‐old man with primary extranodal NK/T‐cell...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718123/ https://www.ncbi.nlm.nih.gov/pubmed/26816549 http://dx.doi.org/10.1111/1759-7714.12254 |
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author | Chien, Chu‐Chun Lee, Herng‐Sheng Lin, Min‐Hsi Hsieh, Pin‐Pen |
author_facet | Chien, Chu‐Chun Lee, Herng‐Sheng Lin, Min‐Hsi Hsieh, Pin‐Pen |
author_sort | Chien, Chu‐Chun |
collection | PubMed |
description | Primary pulmonary non‐Hodgkin's lymphoma (NHL) is very rare. It represents less than 1% of all NHL, and 0.5–1% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL originate from B‐cell lineage. We present a case of a 53‐year‐old man with primary extranodal NK/T‐cell lymphoma of the bronchus and lung, presented progressive dyspnea caused by right lower lung consolidation, and pleural effusion. Initial chest computed tomography suggested advanced lung cancer. Bronchofiberscopy showed a polypoid tumor on which a biopsy was performed. Histologically, the diffusely infiltrative atypical cells were positive for cytoplasmic CD3, CD56, granzyme B, and negative for cytokeratin, CD20 immunostains, suggesting NK/T cell lineages. In situ hybridization for Epstein‐Barr virus encoded ribonucleic acid (EBER) was positive. Herein, we discuss the clinicopathological features of this case and review the literature on primary extranodal NK/T‐cell lymphoma of the lung. Compared with other patients, who died after the first cycle of chemotherapy and/or within three months, our patient had longer survival under aggressive chemotherapy and auto‐peripheral blood stem cell transplantation. |
format | Online Article Text |
id | pubmed-4718123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47181232016-01-26 Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature Chien, Chu‐Chun Lee, Herng‐Sheng Lin, Min‐Hsi Hsieh, Pin‐Pen Thorac Cancer Case Reports Primary pulmonary non‐Hodgkin's lymphoma (NHL) is very rare. It represents less than 1% of all NHL, and 0.5–1% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL originate from B‐cell lineage. We present a case of a 53‐year‐old man with primary extranodal NK/T‐cell lymphoma of the bronchus and lung, presented progressive dyspnea caused by right lower lung consolidation, and pleural effusion. Initial chest computed tomography suggested advanced lung cancer. Bronchofiberscopy showed a polypoid tumor on which a biopsy was performed. Histologically, the diffusely infiltrative atypical cells were positive for cytoplasmic CD3, CD56, granzyme B, and negative for cytokeratin, CD20 immunostains, suggesting NK/T cell lineages. In situ hybridization for Epstein‐Barr virus encoded ribonucleic acid (EBER) was positive. Herein, we discuss the clinicopathological features of this case and review the literature on primary extranodal NK/T‐cell lymphoma of the lung. Compared with other patients, who died after the first cycle of chemotherapy and/or within three months, our patient had longer survival under aggressive chemotherapy and auto‐peripheral blood stem cell transplantation. John Wiley and Sons Inc. 2015-03-19 2016-01 /pmc/articles/PMC4718123/ /pubmed/26816549 http://dx.doi.org/10.1111/1759-7714.12254 Text en © 2015 The Authors. Thoracic Cancer published by China Lung Oncology Group and Wiley Publishing Asia Pty Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Chien, Chu‐Chun Lee, Herng‐Sheng Lin, Min‐Hsi Hsieh, Pin‐Pen Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature |
title | Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature |
title_full | Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature |
title_fullStr | Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature |
title_full_unstemmed | Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature |
title_short | Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature |
title_sort | primary extranodal natural killer/t‐cell lymphoma of bronchus and lung: a case report and review of literature |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718123/ https://www.ncbi.nlm.nih.gov/pubmed/26816549 http://dx.doi.org/10.1111/1759-7714.12254 |
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