Cargando…

Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature

Primary pulmonary non‐Hodgkin's lymphoma (NHL) is very rare. It represents less than 1% of all NHL, and 0.5–1% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL originate from B‐cell lineage. We present a case of a 53‐year‐old man with primary extranodal NK/T‐cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Chien, Chu‐Chun, Lee, Herng‐Sheng, Lin, Min‐Hsi, Hsieh, Pin‐Pen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718123/
https://www.ncbi.nlm.nih.gov/pubmed/26816549
http://dx.doi.org/10.1111/1759-7714.12254
_version_ 1782410744133844992
author Chien, Chu‐Chun
Lee, Herng‐Sheng
Lin, Min‐Hsi
Hsieh, Pin‐Pen
author_facet Chien, Chu‐Chun
Lee, Herng‐Sheng
Lin, Min‐Hsi
Hsieh, Pin‐Pen
author_sort Chien, Chu‐Chun
collection PubMed
description Primary pulmonary non‐Hodgkin's lymphoma (NHL) is very rare. It represents less than 1% of all NHL, and 0.5–1% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL originate from B‐cell lineage. We present a case of a 53‐year‐old man with primary extranodal NK/T‐cell lymphoma of the bronchus and lung, presented progressive dyspnea caused by right lower lung consolidation, and pleural effusion. Initial chest computed tomography suggested advanced lung cancer. Bronchofiberscopy showed a polypoid tumor on which a biopsy was performed. Histologically, the diffusely infiltrative atypical cells were positive for cytoplasmic CD3, CD56, granzyme B, and negative for cytokeratin, CD20 immunostains, suggesting NK/T cell lineages. In situ hybridization for Epstein‐Barr virus encoded ribonucleic acid (EBER) was positive. Herein, we discuss the clinicopathological features of this case and review the literature on primary extranodal NK/T‐cell lymphoma of the lung. Compared with other patients, who died after the first cycle of chemotherapy and/or within three months, our patient had longer survival under aggressive chemotherapy and auto‐peripheral blood stem cell transplantation.
format Online
Article
Text
id pubmed-4718123
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-47181232016-01-26 Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature Chien, Chu‐Chun Lee, Herng‐Sheng Lin, Min‐Hsi Hsieh, Pin‐Pen Thorac Cancer Case Reports Primary pulmonary non‐Hodgkin's lymphoma (NHL) is very rare. It represents less than 1% of all NHL, and 0.5–1% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL originate from B‐cell lineage. We present a case of a 53‐year‐old man with primary extranodal NK/T‐cell lymphoma of the bronchus and lung, presented progressive dyspnea caused by right lower lung consolidation, and pleural effusion. Initial chest computed tomography suggested advanced lung cancer. Bronchofiberscopy showed a polypoid tumor on which a biopsy was performed. Histologically, the diffusely infiltrative atypical cells were positive for cytoplasmic CD3, CD56, granzyme B, and negative for cytokeratin, CD20 immunostains, suggesting NK/T cell lineages. In situ hybridization for Epstein‐Barr virus encoded ribonucleic acid (EBER) was positive. Herein, we discuss the clinicopathological features of this case and review the literature on primary extranodal NK/T‐cell lymphoma of the lung. Compared with other patients, who died after the first cycle of chemotherapy and/or within three months, our patient had longer survival under aggressive chemotherapy and auto‐peripheral blood stem cell transplantation. John Wiley and Sons Inc. 2015-03-19 2016-01 /pmc/articles/PMC4718123/ /pubmed/26816549 http://dx.doi.org/10.1111/1759-7714.12254 Text en © 2015 The Authors. Thoracic Cancer published by China Lung Oncology Group and Wiley Publishing Asia Pty Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Chien, Chu‐Chun
Lee, Herng‐Sheng
Lin, Min‐Hsi
Hsieh, Pin‐Pen
Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature
title Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature
title_full Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature
title_fullStr Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature
title_full_unstemmed Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature
title_short Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature
title_sort primary extranodal natural killer/t‐cell lymphoma of bronchus and lung: a case report and review of literature
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718123/
https://www.ncbi.nlm.nih.gov/pubmed/26816549
http://dx.doi.org/10.1111/1759-7714.12254
work_keys_str_mv AT chienchuchun primaryextranodalnaturalkillertcelllymphomaofbronchusandlungacasereportandreviewofliterature
AT leeherngsheng primaryextranodalnaturalkillertcelllymphomaofbronchusandlungacasereportandreviewofliterature
AT linminhsi primaryextranodalnaturalkillertcelllymphomaofbronchusandlungacasereportandreviewofliterature
AT hsiehpinpen primaryextranodalnaturalkillertcelllymphomaofbronchusandlungacasereportandreviewofliterature