Exploration of Novel Inhibitors for Bruton’s Tyrosine Kinase by 3D QSAR Modeling and Molecular Dynamics Simulation

Bruton’s tyrosine kinase (BTK) is a cytoplasmic, non-receptor tyrosine kinase which is expressed in most of the hematopoietic cells and plays an important role in many cellular signaling pathways. B cell malignancies are dependent on BCR signaling, thus making BTK an efficient therapeutic target. Ov...

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Detalles Bibliográficos
Autores principales: Bavi, Rohit, Kumar, Raj, Choi, Light, Woo Lee, Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718466/
https://www.ncbi.nlm.nih.gov/pubmed/26784025
http://dx.doi.org/10.1371/journal.pone.0147190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718466/
https://www.ncbi.nlm.nih.gov/pubmed/26784025
http://dx.doi.org/10.1371/journal.pone.0147190

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