Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

It has been reported that inhibition of RAD52 either by specific shRNA or a small peptide aptamer induced synthetic lethality in tumor cell lines carrying BRCA1 and BRCA2 inactivating mutations. Molecular docking was used to screen two chemical libraries: 1) 1,217 FDA approved drugs, and 2) 139,735...

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Detalles Bibliográficos
Autores principales: Sullivan, Katherine, Cramer-Morales, Kimberly, McElroy, Daniel L., Ostrov, David A., Haas, Kimberly, Childers, Wayne, Hromas, Robert, Skorski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718542/
https://www.ncbi.nlm.nih.gov/pubmed/26784987
http://dx.doi.org/10.1371/journal.pone.0147230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718542/
https://www.ncbi.nlm.nih.gov/pubmed/26784987
http://dx.doi.org/10.1371/journal.pone.0147230

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