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Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

Piezo1 ion channels mediate the conversion of mechanical forces into electrical signals and are critical for responsiveness to touch in metazoans. The apparent mechanical sensitivity of Piezo1 varies substantially across cellular environments, stimulating methods and protocols, raising the fundament...

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Detalles Bibliográficos
Autores principales: Lewis, Amanda H, Grandl, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718726/
https://www.ncbi.nlm.nih.gov/pubmed/26646186
http://dx.doi.org/10.7554/eLife.12088