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Mechanism of Na(+)-dependent citrate transport from the structure of an asymmetrical CitS dimer

The common human pathogen Salmonella enterica takes up citrate as a nutrient via the sodium symporter SeCitS. Uniquely, our 2.5 Å x-ray structure of the SeCitS dimer shows three different conformations of the active protomer. One protomer is in the outside-facing state. Two are in different inside-f...

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Detalles Bibliográficos
Autores principales: Wöhlert, David, Grötzinger, Maria J, Kühlbrandt, Werner, Yildiz, Özkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718727/
https://www.ncbi.nlm.nih.gov/pubmed/26636752
http://dx.doi.org/10.7554/eLife.09375