Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

Cyclophilin A (CypA) is over-expressed in a number of human cancer types, but the mechanisms by which CypA promotes oncogenic properties of cells are not understood. Here we demonstrate that CypA binds to and prevents the CrkII adaptor protein from switching to the inhibited state. CrkII is involved...

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Detalles Bibliográficos
Autores principales: Saleh, Tamjeed, Jankowski, Wojciech, Sriram, Ganapathy, Rossi, Paolo, Shah, Shreyas, Lee, Ki-Bum, Cruz, Lissette Alicia, Rodriguez, Alexis J., Birge, Raymond B., Kalodimos, Charalampos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718742/
https://www.ncbi.nlm.nih.gov/pubmed/26656091
http://dx.doi.org/10.1038/nchembio.1981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718742/
https://www.ncbi.nlm.nih.gov/pubmed/26656091
http://dx.doi.org/10.1038/nchembio.1981

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