Self-reactive IgE exacerbates interferon responses associated with autoimmunity

Canonically, IgE mediates allergic immune responses by triggering mast cells and basophils to release histamine and Type 2 helper cytokines. Here, we report that in human systemic lupus erythematosus, IgE antibodies specific for double-stranded DNA activate plasmacytoid dendritic cells (pDCs), an im...

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Detalles Bibliográficos
Autores principales: Henault, Jill, Riggs, Jeffrey M., Karnell, Jodi L., Liarski, Vladimir M., Li, Jianqing, Shirinian, Lena, Xu, Linda, Casey, Kerry A., Smith, Michael A., Khatry, Deepak B., Izhak, Liat, Clarke, Lorraine, Herbst, Ronald, Ettinger, Rachel, Petri, Michelle, Clark, Marcus R., Mustelin, Tomas, Kolbeck, Roland, Sanjuan, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718782/
https://www.ncbi.nlm.nih.gov/pubmed/26692173
http://dx.doi.org/10.1038/ni.3326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718782/
https://www.ncbi.nlm.nih.gov/pubmed/26692173
http://dx.doi.org/10.1038/ni.3326

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