Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor-mediated uptake of LDL, and it also mediates cellular entry of Ebola virus. Cholesterol export is inhibited by nanomolar concentrations of U18666A, a cationic sterol. To identify the target of U1866...

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Detalles Bibliográficos
Autores principales: Lu, Feiran, Liang, Qiren, Abi-Mosleh, Lina, Das, Akash, De Brabander, Jef K, Goldstein, Joseph L, Brown, Michael S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718804/
https://www.ncbi.nlm.nih.gov/pubmed/26646182
http://dx.doi.org/10.7554/eLife.12177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718804/
https://www.ncbi.nlm.nih.gov/pubmed/26646182
http://dx.doi.org/10.7554/eLife.12177

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