Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage

Pluripotent stem cells (PSCs) maintain a low mutation frequency compared with somatic cell types at least in part by preferentially utilizing error-free homologous recombination (HR) for DNA repair. Many endogenous metabolites cause DNA interstrand crosslinks, which are repaired by the Fanconi anemi...

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Detalles Bibliográficos
Autores principales: Chlon, Timothy M., Ruiz-Torres, Sonya, Maag, Logan, Mayhew, Christopher N., Wikenheiser-Brokamp, Kathryn A., Davies, Stella M., Mehta, Parinda, Myers, Kasiani C., Wells, James M., Wells, Susanne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719133/
https://www.ncbi.nlm.nih.gov/pubmed/26771352
http://dx.doi.org/10.1016/j.stemcr.2015.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719133/
https://www.ncbi.nlm.nih.gov/pubmed/26771352
http://dx.doi.org/10.1016/j.stemcr.2015.12.001

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