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Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage
Pluripotent stem cells (PSCs) maintain a low mutation frequency compared with somatic cell types at least in part by preferentially utilizing error-free homologous recombination (HR) for DNA repair. Many endogenous metabolites cause DNA interstrand crosslinks, which are repaired by the Fanconi anemi...
Autores principales: | Chlon, Timothy M., Ruiz-Torres, Sonya, Maag, Logan, Mayhew, Christopher N., Wikenheiser-Brokamp, Kathryn A., Davies, Stella M., Mehta, Parinda, Myers, Kasiani C., Wells, James M., Wells, Susanne I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719133/ https://www.ncbi.nlm.nih.gov/pubmed/26771352 http://dx.doi.org/10.1016/j.stemcr.2015.12.001 |
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