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Complementing reversed-phase selectivity with porous graphitized carbon to increase the metabolome coverage in an on-line two-dimensional LC-MS setup for metabolomics

Efficient and robust separation methods are indispensable in modern LC-MS based metabolomics, where high-resolution mass spectrometers are challenged by isomeric and isobaric metabolites. The optimization of chromatographic separation hence remains an invaluable tool in the comprehensive analysis of...

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Detalles Bibliográficos
Autores principales: Ortmayr, Karin, Hann, Stephan, Koellensperger, Gunda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719141/
https://www.ncbi.nlm.nih.gov/pubmed/25824707
http://dx.doi.org/10.1039/c5an00206k