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Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types

BACKGROUND: Large tumor genome sequencing projects have now uncovered a few hundred genes involved in the onset of tumorigenesis, or drivers, in some two dozen malignancies. One of the main challenges emerging from this catalog of drivers is how to make sense of their heterogeneity in most cancer ty...

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Detalles Bibliográficos
Autor principal: Gonzalez-Perez, Abel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719577/
https://www.ncbi.nlm.nih.gov/pubmed/26792175
http://dx.doi.org/10.1186/s13073-015-0260-1