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Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types
BACKGROUND: Large tumor genome sequencing projects have now uncovered a few hundred genes involved in the onset of tumorigenesis, or drivers, in some two dozen malignancies. One of the main challenges emerging from this catalog of drivers is how to make sense of their heterogeneity in most cancer ty...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719577/ https://www.ncbi.nlm.nih.gov/pubmed/26792175 http://dx.doi.org/10.1186/s13073-015-0260-1 |