Tauopathy in transgenic (SHR72) rats impairs function of central noradrenergic system and promotes neuroinflammation

BACKGROUND: Brain norepinephrine (NE) plays an important role in the modulation of stress response and neuroinflammation. Recent studies indicate that in Alzheimer’s disease (AD), the tau neuropathology begins in the locus coeruleus (LC) which is the main source of brain NE. Therefore, we investigat...

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Detalles Bibliográficos
Autores principales: Mravec, Boris, Lejavova, Katarina, Vargovic, Peter, Ondicova, Katarina, Horvathova, Lubica, Novak, Petr, Manz, Georg, Filipcik, Peter, Novak, Michal, Kvetnansky, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719584/
https://www.ncbi.nlm.nih.gov/pubmed/26792515
http://dx.doi.org/10.1186/s12974-016-0482-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719584/
https://www.ncbi.nlm.nih.gov/pubmed/26792515
http://dx.doi.org/10.1186/s12974-016-0482-1

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