Cargando…

Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells

Medullary thymic epithelial cells (mTECs) are essential for establishing central tolerance by expressing a diverse array of self-peptides that delete autoreactive thymocytes and/or divert thymocytes into the regulatory T cell lineage. Activation of the NFκB signaling pathway in mTEC precursors is in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lomada, Dakshayani, Jain, Manju, Bolner, Michelle, Reeh, Kaitlin A. G., Kang, Rhea, Reddy, Madhava C., DiGiovanni, John, Richie, Ellen R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720390/ https://www.ncbi.nlm.nih.gov/pubmed/26789196 http://dx.doi.org/10.1371/journal.pgen.1005777

Ejemplares similares

Molecular docking analysis of C-phycocyanin with VEGFR2
por: Bannu, Saira M, et al.
Publicado: (2020)

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells
por: Satoh, Rumi, et al.
Publicado: (2016)

A Homology Based Model and Virtual Screening of Inhibitors for Human Geranylgeranyl Transferase 1 (GGTase1)
por: Thippanna, Mallikarjuna, et al.
Publicado: (2013)

Molecular docking and simulation of Curcumin with Geranylgeranyl Transferase1 (GGTase1) and Farnesyl Transferase (FTase)
por: Subramani, Parasuraman Aiya, et al.
Publicado: (2015)

Immunomodulatory properties of titanium dioxide nanostructural materials
por: Latha, T. Sree, et al.
Publicado: (2017)

FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells
por: Sun, Lina, et al.
Publicado: (2015)

γδ T Cell-Mediated Immune Responses in Disease and Therapy
por: Latha, T. Sree, et al.
Publicado: (2014)

Isolation and in vitro evaluation of bacteriophages against MDR-bacterial isolates from septic wound infections
por: Pallavali, Roja Rani, et al.
Publicado: (2017)

AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma
por: Matsumoto, Minoru, et al.
Publicado: (2023)

Antioxidant Efficacy of Green-Synthesized Silver Nanoparticles Promotes Wound Healing in Mice
por: Lakkim, Vajravathi, et al.
Publicado: (2023)

Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?
por: Farr, Andrew G., et al.
Publicado: (1998)

Serial progression of cortical and medullary thymic epithelial microenvironments
por: Alves, Nuno L, et al.
Publicado: (2014)

Transcriptomic diversity in human medullary thymic epithelial cells
por: Carter, Jason A., et al.
Publicado: (2022)

Medullary Thymic Epithelial Cell Antigen-presentation Assays
por: Borelli, Alexia, et al.
Publicado: (2023)

Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model
por: Lakkim, Vajravathi, et al.
Publicado: (2020)

Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitors
por: Baik, Song, et al.
Publicado: (2016)

Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality
por: Villegas, José A., et al.
Publicado: (2018)

Foxn1 Regulates Lineage Progression in Cortical and Medullary Thymic Epithelial Cells But Is Dispensable for Medullary Sublineage Divergence
por: Nowell, Craig S., et al.
Publicado: (2011)

A Common Stem Cell for Murine Cortical and Medullary Thymic Epithelial Cells?
por: Röpke, Carsten, et al.
Publicado: (1995)

Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells
Publicado: (1992)

Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin
por: Danzl, Nichole M., et al.
Publicado: (2010)

TNF receptor family signaling in the development and functions of medullary thymic epithelial cells
por: Akiyama, Taishin, et al.
Publicado: (2012)

DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells
por: Wu, Guoying, et al.
Publicado: (2012)

microRNA-449a modulates medullary thymic epithelial cell differentiation
por: Chen, Pengfei, et al.
Publicado: (2017)

Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes
por: Speck-Hernandez, Cesar A., et al.
Publicado: (2018)

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
por: Lucas, Beth, et al.
Publicado: (2020)

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
por: Lopes, Noella, et al.
Publicado: (2022)

Single-cell transcriptome analysis reveals coordinated ectopic gene expression patterns in medullary thymic epithelial cells
por: Brennecke, Philip, et al.
Publicado: (2015)

INCORPORATION OF SULFATE BY THE MOUSE THYMUS: ITS RELATION TO SECRETION BY MEDULLARY EPITHELIAL CELLS AND TO THYMIC LYMPHOPOIESIS
por: Clark, Sam L.
Publicado: (1968)

An Essential Role for Medullary Thymic Epithelial Cells during the Intrathymic Development of Invariant NKT Cells
por: White, Andrea J., et al.
Publicado: (2014)

Regulations of Gene Expression in Medullary Thymic Epithelial Cells Required for Preventing the Onset of Autoimmune Diseases
por: Akiyama, Taishin, et al.
Publicado: (2013)

Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors
por: Baik, Song, et al.
Publicado: (2013)

Positive and Negative Regulatory Mechanisms for Fine-Tuning Cellularity and Functions of Medullary Thymic Epithelial Cells
por: Akiyama, Taishin, et al.
Publicado: (2015)

Aire Gene Influences the Length of the 3′ UTR of mRNAs in Medullary Thymic Epithelial Cells
por: Oliveira, Ernna H., et al.
Publicado: (2020)

Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells
por: Dhalla, Fatima, et al.
Publicado: (2019)

A novel method to identify Post‐Aire stages of medullary thymic epithelial cell differentiation
por: Ferreirinha, Pedro, et al.
Publicado: (2020)

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
por: Yasumizu, Yoshiaki, et al.
Publicado: (2022)

STAT3 expression correlates with prognosis of thymic epithelial tumors
por: Li, Chao, et al.
Publicado: (2013)

Meis1 Is Required for the Maintenance of Postnatal Thymic Epithelial Cells
por: Hirayama, Takehiro, et al.
Publicado: (2014)

Adult Thymus Contains FoxN1(−) Epithelial Stem Cells that Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages
por: Ucar, Ahmet, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_919o7m758m43f77tefkk09mhan