MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice

It remains challenging to produce decisive vaccines against MUC1, a tumor-associated antigen widely expressed by pancreas, breast and other tumors. Employing clinically relevant mouse models, we ruled out such causes as irreversible T-cell tolerance, inadequate avidity, and failure of T-cells to rec...

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Detalles Bibliográficos
Autores principales: Lakshminarayanan, Vani, Supekar, Nitin T., Wei, Jie, McCurry, Dustin B., Dueck, Amylou C., Kosiorek, Heidi E., Trivedi, Priyanka P., Bradley, Judy M., Madsen, Cathy S., Pathangey, Latha B., Hoelzinger, Dominique B., Wolfert, Margreet A., Boons, Geert-Jan, Cohen, Peter A., Gendler, Sandra J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720451/
https://www.ncbi.nlm.nih.gov/pubmed/26788922
http://dx.doi.org/10.1371/journal.pone.0145920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720451/
https://www.ncbi.nlm.nih.gov/pubmed/26788922
http://dx.doi.org/10.1371/journal.pone.0145920

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