Altered neuronal network and rescue in a human MECP2 duplication model

Increased dosage of MeCP2 results in a dramatic neurodevelopmental phenotype with onset at birth. We generated induced pluripotent stem cells (iPSC) from patients with the MECP2 duplication syndrome (MECP2dup), carrying different duplication sizes, to study the impact of increased MeCP2 dosage in hu...

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Detalles Bibliográficos
Autores principales: Nageshappa, Savitha, Carromeu, Cassiano, Trujillo, Cleber A., Mesci, Pinar, Espuny-Camacho, Ira, Pasciuto, Emanuela, Vanderhaeghen, Pierre, Verfaillie, Catherine, Raitano, Susanna, Kumar, Anujith, Carvalho, Claudia M.B., Bagni, Claudia, Ramocki, Melissa B., Araujo, Bruno H. S., Torres, Laila B., Lupski, James R., Van Esch, Hilde, Muotri, Alysson R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720528/
https://www.ncbi.nlm.nih.gov/pubmed/26347316
http://dx.doi.org/10.1038/mp.2015.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720528/
https://www.ncbi.nlm.nih.gov/pubmed/26347316
http://dx.doi.org/10.1038/mp.2015.128

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