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The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost

Accumulation of the microtubule associated protein tau occurs in several neurodegenerative diseases including Alzheimer's disease (AD). The tau protein is intrinsically disordered, giving it unique structural properties that can be dynamically altered by post-translational modifications such as...

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Detalles Bibliográficos
Autores principales: Sabbagh, Jonathan J., Dickey, Chad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720746/
https://www.ncbi.nlm.nih.gov/pubmed/26834532
http://dx.doi.org/10.3389/fnins.2016.00003