Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells

The multidrug resistance (MDR) phenotype often accompanies activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, which renders a survival signal to withstand cytotoxic anticancer drugs and enhances cancer stem cell (CSC) characteristics. As a result, PI3K/AKT-blocking approaches have b...

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Detalles Bibliográficos
Autores principales: Hu, Y, Guo, R, Wei, J, Zhou, Y, Ji, W, Liu, J, Zhi, X, Zhang, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720896/
https://www.ncbi.nlm.nih.gov/pubmed/26673665
http://dx.doi.org/10.1038/cddis.2015.363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720896/
https://www.ncbi.nlm.nih.gov/pubmed/26673665
http://dx.doi.org/10.1038/cddis.2015.363

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