Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

Leber's hereditary optic neuropathy (LHON), the most frequent mitochondrial disease, is associated with mitochondrial DNA (mtDNA) point mutations affecting Complex I subunits, usually homoplasmic. This blinding disorder is characterized by incomplete penetrance, possibly related to several gene...

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Detalles Bibliográficos
Autores principales: Giordano, L, Deceglie, S, d'Adamo, P, Valentino, M L, La Morgia, C, Fracasso, F, Roberti, M, Cappellari, M, Petrosillo, G, Ciaravolo, S, Parente, D, Giordano, C, Maresca, A, Iommarini, L, Del Dotto, V, Ghelli, A M, Salomao, S R, Berezovsky, A, Belfort, R, Sadun, A A, Carelli, V, Loguercio Polosa, P, Cantatore, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720897/
https://www.ncbi.nlm.nih.gov/pubmed/26673666
http://dx.doi.org/10.1038/cddis.2015.364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720897/
https://www.ncbi.nlm.nih.gov/pubmed/26673666
http://dx.doi.org/10.1038/cddis.2015.364

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