An in vivo platform for identifying inhibitors of protein aggregation

Protein aggregation underlies an array of human diseases, yet only one small molecule therapeutic has been successfully developed to date. Here, we introduce an in vivo system, based on a β-lactamase tripartite fusion construct, capable of identifying aggregation-prone sequences in the periplasm of...

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Detalles Bibliográficos
Autores principales: Saunders, Janet C., Young, Lydia M., Mahood, Rachel A., Jackson, Matthew P., Revill, Charlotte H., Foster, Richard J., Smith, D. Alastair, Ashcroft, Alison E., Brockwell, David J., Radford, Sheena E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720988/
https://www.ncbi.nlm.nih.gov/pubmed/26656088
http://dx.doi.org/10.1038/nchembio.1988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720988/
https://www.ncbi.nlm.nih.gov/pubmed/26656088
http://dx.doi.org/10.1038/nchembio.1988

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