Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1α down-regulation in metastatic cells

BACKGROUND: The three members of the human heterochromatin protein 1 (HP1) family of proteins, HP1α, HP1β, and HPγ, are involved in chromatin packing and epigenetic gene regulation. HP1α is encoded from the CBX5 gene and is a suppressor of metastasis. CBX5 is down-regulated at the transcriptional an...

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Detalles Bibliográficos
Autores principales: Vad-Nielsen, Johan, Jakobsen, Kristine Raaby, Daugaard, Tina Fuglsang, Thomsen, Rune, Brügmann, Anja, Sørensen, Boe Sandahl, Nielsen, Anders Lade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721113/
https://www.ncbi.nlm.nih.gov/pubmed/26791953
http://dx.doi.org/10.1186/s12885-016-2059-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721113/
https://www.ncbi.nlm.nih.gov/pubmed/26791953
http://dx.doi.org/10.1186/s12885-016-2059-x

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