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Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog
BACKGROUND: Endostatin (ES) is a well-established potent endogenous antiangiogenic factor. An ES variant, called zinc-binding protein-ES (ZBP-ES), is clinically available; however, its use is limited by rapid renal clearance and short residence time. PEGylation has been exploited to overcome these s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721152/ https://www.ncbi.nlm.nih.gov/pubmed/26792627 http://dx.doi.org/10.1186/s40880-016-0080-8 |