Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain

Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors. Of these, group III mGlu receptors (mGlu 4, 6, 7, 8) are among the least studied due to a lack of pharmacological tools. mGlu7 receptors, the most highly co...

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Detalles Bibliográficos
Autores principales: Moloney, Rachel D., Golubeva, Anna V., O'Connor, Richard M., Kalinichev, Mikhail, Dinan, Timothy G., Cryan, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721404/
https://www.ncbi.nlm.nih.gov/pubmed/26844237
http://dx.doi.org/10.1016/j.ynstr.2015.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721404/
https://www.ncbi.nlm.nih.gov/pubmed/26844237
http://dx.doi.org/10.1016/j.ynstr.2015.04.001

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