Entrapment of a Histone Tail by a DNA Lesion in a Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular Dynamics Study

[Image: see text] Errors in epigenetic markings are associated with human diseases, including cancer. We have used molecular dynamics simulations of a nucleosome containing the 10S (+)-trans-anti-B[a]P-N(2)-dG lesion, derived from the environmental pro-carcinogen benzo[a]pyrene, to elucidate the imp...

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Detalles Bibliográficos
Autores principales: Fu, Iwen, Cai, Yuqin, Zhang, Yingkai, Geacintov, Nicholas E., Broyde, Suse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721520/
https://www.ncbi.nlm.nih.gov/pubmed/26709619
http://dx.doi.org/10.1021/acs.biochem.5b01166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721520/
https://www.ncbi.nlm.nih.gov/pubmed/26709619
http://dx.doi.org/10.1021/acs.biochem.5b01166

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