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Entrapment of a Histone Tail by a DNA Lesion in a Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular Dynamics Study
[Image: see text] Errors in epigenetic markings are associated with human diseases, including cancer. We have used molecular dynamics simulations of a nucleosome containing the 10S (+)-trans-anti-B[a]P-N(2)-dG lesion, derived from the environmental pro-carcinogen benzo[a]pyrene, to elucidate the imp...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721520/ https://www.ncbi.nlm.nih.gov/pubmed/26709619 http://dx.doi.org/10.1021/acs.biochem.5b01166 |
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author | Fu, Iwen Cai, Yuqin Zhang, Yingkai Geacintov, Nicholas E. Broyde, Suse |
author_facet | Fu, Iwen Cai, Yuqin Zhang, Yingkai Geacintov, Nicholas E. Broyde, Suse |
author_sort | Fu, Iwen |
collection | PubMed |
description | [Image: see text] Errors in epigenetic markings are associated with human diseases, including cancer. We have used molecular dynamics simulations of a nucleosome containing the 10S (+)-trans-anti-B[a]P-N(2)-dG lesion, derived from the environmental pro-carcinogen benzo[a]pyrene, to elucidate the impact of the lesion on the structure and dynamics of a nearby histone N-terminal tail. Our results show that a lysine-containing part of this H2B tail that is subject to post-translational modification is engulfed by the enlarged DNA minor groove imposed by the lesion. The tail entrapment suggests that epigenetic markings could be hampered by this lesion, thereby impacting critical cellular functions, including transcription and repair. |
format | Online Article Text |
id | pubmed-4721520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | American
Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-47215202016-12-28 Entrapment of a Histone Tail by a DNA Lesion in a Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular Dynamics Study Fu, Iwen Cai, Yuqin Zhang, Yingkai Geacintov, Nicholas E. Broyde, Suse Biochemistry [Image: see text] Errors in epigenetic markings are associated with human diseases, including cancer. We have used molecular dynamics simulations of a nucleosome containing the 10S (+)-trans-anti-B[a]P-N(2)-dG lesion, derived from the environmental pro-carcinogen benzo[a]pyrene, to elucidate the impact of the lesion on the structure and dynamics of a nearby histone N-terminal tail. Our results show that a lysine-containing part of this H2B tail that is subject to post-translational modification is engulfed by the enlarged DNA minor groove imposed by the lesion. The tail entrapment suggests that epigenetic markings could be hampered by this lesion, thereby impacting critical cellular functions, including transcription and repair. American Chemical Society 2015-12-28 2016-01-19 /pmc/articles/PMC4721520/ /pubmed/26709619 http://dx.doi.org/10.1021/acs.biochem.5b01166 Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Fu, Iwen Cai, Yuqin Zhang, Yingkai Geacintov, Nicholas E. Broyde, Suse Entrapment of a Histone Tail by a DNA Lesion in a Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular Dynamics Study |
title | Entrapment of a Histone Tail by a DNA Lesion in a
Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular
Dynamics Study |
title_full | Entrapment of a Histone Tail by a DNA Lesion in a
Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular
Dynamics Study |
title_fullStr | Entrapment of a Histone Tail by a DNA Lesion in a
Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular
Dynamics Study |
title_full_unstemmed | Entrapment of a Histone Tail by a DNA Lesion in a
Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular
Dynamics Study |
title_short | Entrapment of a Histone Tail by a DNA Lesion in a
Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular
Dynamics Study |
title_sort | entrapment of a histone tail by a dna lesion in a
nucleosome suggests the lesion impacts epigenetic marking: a molecular
dynamics study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721520/ https://www.ncbi.nlm.nih.gov/pubmed/26709619 http://dx.doi.org/10.1021/acs.biochem.5b01166 |
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