Cargando…

Esters of Bendamustine Are by Far More Potent Cytotoxic Agents than the Parent Compound against Human Sarcoma and Carcinoma Cells

The alkylating agent bendamustine is approved for the treatment of hematopoietic malignancies such as non-Hodgkin lymphoma, chronic lymphocytic leukemia and multiple myeloma. As preliminary data on recently disclosed bendamustine esters suggested increased cytotoxicity, we investigated representativ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huber, Stefan, Huettner, Johannes Philip, Hacker, Kristina, Bernhardt, Günther, König, Jörg, Buschauer, Armin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721923/ https://www.ncbi.nlm.nih.gov/pubmed/26196503 http://dx.doi.org/10.1371/journal.pone.0133743

Ejemplares similares

The Extracellular Loop 2 (ECL2) of the Human Histamine H(4) Receptor Substantially Contributes to Ligand Binding and Constitutive Activity
por: Wifling, David, et al.
Publicado: (2015)

A split luciferase-based probe for quantitative proximal determination of Gα(q) signalling in live cells
por: Littmann, Timo, et al.
Publicado: (2018)

Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H(2) Receptor Agonists†
por: Pockes, Steffen, et al.
Publicado: (2018)

Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H(4) Receptor Orthologs: Correlations and Discrepancies between Distal and Proximal Readouts
por: Nordemann, Uwe, et al.
Publicado: (2013)

The Neuropeptide Y Y(1) Receptor: A Diagnostic Marker? Expression in MCF-7 Breast Cancer Cells Is Down-Regulated by Antiestrogens In Vitro and in Xenografts
por: Memminger, Martin, et al.
Publicado: (2012)

In Search of NPY Y(4)R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists
por: Kuhn, Kilian K., et al.
Publicado: (2017)

Immunological reactions induced by bendamustine
por: Sanchez-Gonzalez, Maria-Jose, et al.
Publicado: (2014)

The physiology of vitamin D—far more than calcium and bone
por: Carlberg, Carsten
Publicado: (2014)

BK K(+) channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells
por: Edalat, Lena, et al.
Publicado: (2016)

Randomized phase 2 study of otlertuzumab and bendamustine versus bendamustine in patients with relapsed chronic lymphocytic leukaemia
por: Robak, Tadeusz, et al.
Publicado: (2016)

MRD response in relapsed/refractory FL after obinutuzumab plus bendamustine or bendamustine alone in the GADOLIN trial
por: Pott, Christiane, et al.
Publicado: (2019)

Bendamustine in the treatment of non-Hodgkin’s lymphomas
por: Hagemeister, Fredrick, et al.
Publicado: (2009)

Bendamustine Associated with Irreversible Ascending Paralysis
por: Alhafez, Ashraf, et al.
Publicado: (2013)

Lichenoid drug eruption associated with Bendamustine
por: Kusano, Y, et al.
Publicado: (2016)

Large Hadron Collider more whimper than bang so far
Publicado: (2008)

Glioma-Derived Extracellular Vesicles – Far More Than Local Mediators
por: Tankov, Stoyan, et al.
Publicado: (2021)

Are genotoxic carcinogens more potent than nongenotoxic carcinogens?
por: Parodi, S, et al.
Publicado: (1991)

Bendamustine in patients with relapsed or refractory multiple myeloma
por: Michael, M, et al.
Publicado: (2010)

Role of bendamustine in the treatment of chronic lymphocytic leukemia
por: Jamshed, Saad, et al.
Publicado: (2009)

Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites
por: Darwish, Mona, et al.
Publicado: (2015)

Herpetic esophagitis following bendamustine-containing regimen
por: Yamane, Hiromichi, et al.
Publicado: (2016)

Inhibition of STAT3 by Anticancer Drug Bendamustine
por: Iwamoto, Kazunori, et al.
Publicado: (2017)

Immunomodulatory Effects of Bendamustine in Hematopoietic Cell Transplantation
por: Stokes, Jessica, et al.
Publicado: (2021)

Reduced bendamustine for elderly patients with follicular lymphoma
por: Masamoto, Yosuke, et al.
Publicado: (2021)

Bendamustine and pneumocystis pneumonia: A systematic review
por: Hakamifard, Atousa, et al.
Publicado: (2022)

Rituximab and Bendamustine (BR) Compared with Rituximab, Bendamustine, and Cytarabine (R-BAC) in Previously Untreated Elderly Patients with Mantle Cell Lymphoma
por: Bega, Giulia, et al.
Publicado: (2021)

SAGE is far more sensitive than EST for detecting low-abundance transcripts
por: Sun, Miao, et al.
Publicado: (2004)

' My training prepared me for far more than just clinical dentistry'
por: Clarke, Sophie
Publicado: (2020)

FARS2 Mutations: More Than Two Phenotypes? A Case Report
por: Hotait, Mostafa, et al.
Publicado: (2020)

Beneficial Effects of Melatonin on Periodontitis Management: Far More Than Oral Cavity
por: Wang, Chuan, et al.
Publicado: (2022)

Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma
por: Gallego-Lleyda, Ana, et al.
Publicado: (2018)

Uterine sarcoma: almost more tumor than patient
por: Ellis, Laura Burney, et al.
Publicado: (2023)

Venetoclax plus bendamustine-rituximab or bendamustine-obinutuzumab in chronic lymphocytic leukemia: final results of a phase Ib study (GO28440)
por: Stilgenbauer, Stephan, et al.
Publicado: (2020)

Is Articaine More Potent than Mepivacaine for Use in Oral Surgery?
por: Gazal, Giath
Publicado: (2018)

The role of bendamustine in the treatment of indolent non-Hodgkin lymphoma
por: Aldoss, Ibrahim T, et al.
Publicado: (2009)

Severe Dermatologic Reactions with Bendamustine: A Case Series
por: Carilli, Allison, et al.
Publicado: (2014)

Bendamustine, pomalidomide, and dexamethasone for relapsed and/or refractory multiple myeloma
por: Sivaraj, Dharshan, et al.
Publicado: (2018)

Skin testing with bendamustine: what concentration should be used?
por: Malinauskiene, Laura, et al.
Publicado: (2020)

Bendamustine/dexamethasone/rituximab: Cytomegalovirus reactivation : case report
Publicado: (2021)

Bendamustine/rituximab: COVID-19 pneumonia: case report
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a4upqv9b3ln0ubpbbccosudt6g