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Essentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatis

Discovery of mupirocin, an antibiotic that targets isoleucyl-tRNA synthetase, established aminoacyl-tRNA synthetase as an attractive target for the discovery of novel antibacterial agents. Despite a high degree of similarity between the bacterial and human aminoacyl-tRNA synthetases, the selectivity...

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Detalles Bibliográficos
Autores principales:	Ravishankar, Sudha, Ambady, Anisha, Swetha, Rayapadi G., Anbarasu, Anand, Ramaiah, Sudha, Sambandamurthy, Vasan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721953/ https://www.ncbi.nlm.nih.gov/pubmed/26794499 http://dx.doi.org/10.1371/journal.pone.0147188

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