The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis

Little is known on post-transcriptional regulation of adult and embryonic stem cell maintenance and differentiation. Here we characterize the role of Ddb1, a component of the CUL4-DDB1 ubiquitin ligase complex. Ddb1 is highly expressed in multipotent hematopoietic progenitors and its deletion leads...

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Detalles Bibliográficos
Autores principales: Gao, Jie, Buckley, Shannon M, Cimmino, Luisa, Guillamot, Maria, Strikoudis, Alexandros, Cang, Yong, Goff, Stephen P, Aifantis, Iannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721963/
https://www.ncbi.nlm.nih.gov/pubmed/26613412
http://dx.doi.org/10.7554/eLife.07539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721963/
https://www.ncbi.nlm.nih.gov/pubmed/26613412
http://dx.doi.org/10.7554/eLife.07539

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