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cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

Adenosine 3',5'-cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the Na(+)-K(+)-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase cAMP levels but its effects on the atrium are not underst...

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Detalles Bibliográficos
Autores principales: Peng, Li-qun, Li, Ping, Zhang, Qiu-li, Hong, Lan, Liu, Li-ping, Cui, Xun, Cui, Bai-ri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722196/
https://www.ncbi.nlm.nih.gov/pubmed/26807018
http://dx.doi.org/10.4196/kjpp.2016.20.1.9