Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity

Diverse lines of evidence suggest that amyloid-β (Aβ) peptides causally contribute to the pathogenesis of Alzheimer disease (AD), the most frequent neurodegenerative disorder. However, the mechanisms by which Aβ impairs neuronal functions remain to be fully elucidated. Previous studies showed that s...

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Detalles Bibliográficos
Autores principales: Miyamoto, Takashi, Kim, Daniel, Knox, Joseph A., Johnson, Erik, Mucke, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722453/
https://www.ncbi.nlm.nih.gov/pubmed/26589795
http://dx.doi.org/10.1074/jbc.M115.666529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722453/
https://www.ncbi.nlm.nih.gov/pubmed/26589795
http://dx.doi.org/10.1074/jbc.M115.666529

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